Monday, July 13, 2009

Drug Delivery

Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications

Lipospheres in Drug Targets and Delivery: Approaches, Methods, and Applications presents an overview of the most recent applications of lipospheres primarily in the field of medicine, pharmaceutics and biotechnology. Included are chapters on preparation, characterization, delivery (of peptides, proteins, vaccines, nucleic acids) therapeutic applications to different systems and suggestions for further research. Including numerous illustrations, tables and photos, this book provides procedures for specific applications and biological systems and shows lipospheres as a technical solution to various problems associated with controlled release of biochemicals.

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Handbook of Pharmaceutical Controlled Release Technology


Cambridge Scientific, Inc., MA. Review the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices and membrane-controlled reservoir, bioerodible, and pendant chain systems. Expanded-outline format.

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Encyclopedia of Pharmaceutical Technology, Volume 20

AAI, Inc., Wilmington, NC. An encyclopedia of pharmaceutical technology, offering a collection of entries on a number of subjects, from drug delivery to process chemistry in the pharmaceutical industry. Lists the contents for all 20 volumes in the set. DNLM: Chemistry, Pharmaceutical-encyclopedias.
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This volume provides coverage assisted transdermal and topical delivery by mechanisms of iontophoresis, electroosmosis and electroporation. Other topics discussed are human and clinical studies with iontophoresis, such As Delivery Of Peptides, Proteins And Oligonucleotides, And Other developments.
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Drug Delivery Systems, Second Edition


Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both industry and academia. New in this edition: · Chapter focusing on novel technologies and their global outlook · Coverage of electronically controlled drug delivery · Macrocapsules and nanoparticles in drug targeting · Drug nanocrystals and other new delivery systems · Updated information on liposomes as carriers Written in a straightforward, clear, and concise manner, the author provides a global perspective on current and future advances and market opportunities. Drug Delivery Systems, Second Edition answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development.
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Nanotherapeutics: Drug Delivery Concepts in Nanoscience

An important and exciting aspect in the newly developing field of nanomedicine is the use of nanoparticle drug delivery systems allowing for innovative therapeutic approaches. Due to their small size, these drug delivery systems are promising tools in therapeutic approaches such as selective or targeted drug delivery towards a specific tissue or organ, enhanced drug transport across biological barriers, and intracellular drug delivery.
This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g. diabetes, cancer, inflammation, etc.) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. Written in a concise manner, readers will gain an insight into the basics of nanoparticle preparation as well as a more detailed account of what is therapeutically feasible by using nanoparticle approaches.
Contents: General Aspects of Nanotherapeutics: Nanocarriers in Drug Delivery - Design, Manufacture and Physicochemical Properties (C Schmidt & A Lamprecht); Transport Across Biological Barriers (N Nafee et al.); Targeting Approaches (S Cammas-Marion); Disease-Related Approaches by Nanotherapeutics: Nanoscale Cancer Therapeutics (Y Pellequer & A Lamprecht); Nanotherapeutics for Skin Diseases (N Atrux-Tallau et al.); Nanoparticles for Oral Vaccination (J M Irache et al.); Nanoparticles: Therapeutic Approaches for Bacterial Diseases (B Moulari); Nanoparticle Therapy in Parasites Diseases: Possibility and Reality! (M Larabi); Nanocarriers in the Therapy of Inflammatory Disease (A Lamprecht).
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Delivery System Handbook for Personal Care and Cosmetic Products :
Technology, Applications and Formulations



Novel delivery systems designed to facilitate the use of “fountain of youth” and other functional actives is an idea whose time has come. In a rapidly growing global market eager for products that really work, accelerating market pull and technology push forces have set the stage for this Foundation text. This “must have” book is the first volume of a new series entitled “Breakthroughs in Personal Care and Cosmetic Technology.” It has been carefully designed for training, development, and the empowerment of synergistic technology transfer across the personal care, cosmetic, and pharmaceutical industries.
This book is intended to cause a breakthrough in effective communication and interaction among technology and marketing functions. It is a showcase for understanding, using, and marketing the technology of why and how delivery systems work, as well as current, emerging/potential applications and working formulations. Each chapter is written by one or more experts in the field. A wide range of companies serving the global marketplace are represented. These companies offer numerous types of delivery systems containing highly desirable functional actives, delivery system technology development services, and opportunities for technology licensing, mergers, and acquisitions. A unique feature of the book is the use of Mind Map™ technology to capture and present the essence of the inner-thinking of over 80 authors in a Book-at-a-Glance Executive Overview section. This section has been specifically designed to powerfully impact decision making leading to the development of innovative product differentiation in a global context.
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Assessing Bioavailablility of Drug Delivery Systems: Mathematical Modeling


This book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The mathematical models developed by the author are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency, and to determine the best dosage forms necessary for therapy.

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Wednesday, July 8, 2009

Physiology collection

BRS Physiology

Linda S Costanzo “BRS Physiology"
Lippincott Williams & Wilkins 2006-07-01
ISBN: 0781773113 352 pages PDF 13,9 Mb

Thoroughly updated for its Fourth Edition, BRS Physiology is an excellent aid for students preparing for the USMLE Step 1. The book concisely reviews key physiological principles and includes clinical correlations throughout to emphasize connections between basic physiology and clinical medicine. Numerous illustrations, tables, and flow charts help students visualize material quickly and aid in long-term retention. End-of-chapter USMLE-style questions and a comprehensive end-of-book exam test the student's problem-solving skills, and clearly explained answers guide the student through the correct steps in reasoning. This edition features increased coverage of pathophysiology, new questions, and a new two-color design and artwork.

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Illustrated Physiology

Paperback: 325 pagesData: January 1997
Format: PDF

Description: University of Glasgow, U.K. Introductory physiology textbook, for nursing and allied health students. Emphasis on illustrating physiology concepts with minimal textual information. New information on immunity, the autonomic nervous system, and the renal system. Softcover. Previous edition 1990.

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Vander et al's Human Physiology

Eric P. Widmaier, Hershel Raff, Kevin T. Strang, "Vander et al's Human Physiology:The Mechanisms of Body Function"
ISBN: 0072880740
Publisher: McGraw-Hill Companies

The purpose of this book remains what it was in the first eight editions “to present the fundamental principles and facts of human physiology in a format that is suitable for undergraduate students regardless of academic backgrounds or fields of study “ liberal arts, biology, nursing, pharmacy, or, other allied health professions. The book is also suitable for dental students and many medical students have also used previous editions to lay the foundation for the more detailed coverage they receive in their courses.
This is the best book I've ever seen in Physiology. I enjoyed very much while studying physiology from this book for 2 years.
OverviewThe ninth edition of this classic text has been entrusted into the capable hands of a dynamic new author team. Eric Widmaier, Hershel Raff, and Kevin Strang have taken on the challenge of maintaining the strengths and reputation that have long been the hallmark of Human Physiology: The Mechanisms of Body Function. The fundamental purpose of this textbook has remained undeniably the same: to present the principles and facts of human physiology in a format that is suitable for undergraduates regardless of academic background or field of study. Human Physiology, ninth edition, carries on the tradition of clarity and accuracy, while refining and updating the content to meet the needs of today's instructors and students. The ninth edition features a streamlined, clinically oriented focus to the study of human body systems. Widmaier is considered higher level than Human Physiology by Stuart Fox, due to its increased emphasis on the mechanisms of body functions.
ContentsChapter 1 Homeostasis: A Framework for Human Physiology.Chapter 2 Chemical Composition of the Body.Chapter 3 Cell Structure and Protein Function.Chapter 4 Movement of Molecules Across Cell.Chapter 5 Control of Cells by Chemical Messengers.Chapter 6 Neuronal Signaling and the Structure of the Nervous System.Chapter 7 Sensory Physiology.Chapter 8 Consciousness, the Brain, and Behavior.Chapter 9 Muscle.Chapter 10 Control of Body Movement.Chapter 11 The Endocrine System.Chapter 12 Cardiovascular Physiology.Chapter 13 Respiratory Physiology.Chapter 14 The Kidneys and Regulation of Water and Inorganic Ions.Chapter 15 The Digestion and Absorption of Food.Chapter 16 Regulation of Organic Metabolism and Energy Balance.Chapter 17 Reproduction.Chapter 18 Defense Mechanisms of the Body.

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Netter's Atlas of Human Physiology

John T. Hansen, Bruce M. Koeppen, ?Netter's Atlas of Human Physiology? Saunders
ISBN: 1929007019 1st edition (May 15, 2002) PDF 223 pages 24.1 MB

Organ structure and function come alive with 282 of Dr. Netter's beautifully rendered color drawings and schematics. Each chapter progresses from the important overview relationships of organ system physiology down to the tissue, cellular, and subcellular levels.

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Human PhysiologyHuman Physiology
Publisher:McGraw Hill Higher Education Pages:736 2004
ISBN: 0072919280 PDF 193 MB

Clear explanations and a solid learning framework have been market tested and refined. Fox help students master the fundamentals by providing appropriate anatomical detail.Human Physiology is intended for the one-semester Human Physiology course often taken by allied health and other biology students. The beginning chapters introduce basic chemical and biological concepts to provide students with the framework they need to comprehend physiological principles. The chapters that follow promote conceptual understanding rather than rote memorization of facts.Health applications are included throughout the book to heighten interest, deepen understanding of physiological concepts, and help students relate the material to their individual career goals. Every effort has been made to help students integrate related concepts and understand the relationships between anatomical structures and their functions.

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Drug Delivery System

Pharmaceutical gene drug delivery systems


This reference discusses advances in the design, optimization, and adaption of gene delivery systems for treatment of cancerous, cardiovascular, pulmonary, genetic, and infectious diseases. Pharmaceutical Gene Delivery Systems also contains assessment and reviews on procedures involved in the development of gene-based pharmaceuticals. It examines the advantages and limitations of the major gene delivery systems, as well as offers guidelines to select the most appropriate viral or synthetic delivery system for specific theraputic applications. Pharmaceutical Gene Delivery: • examines recent breakthroughs in gene therapy • details new technologies such as artificial chromosome delivery • covers the preclinical data required for investigational new drug applicationfiling • exemplifies several therapeutic applications of gene therapy products Contents 1. Introduction to Gene Therapy and Guidelines to Pharmaceutical Development 2. Sustaining Transgene _Expression in Vivo 3. _Expression Systems: Regulated Gene _Expression 4. Mechanisms for Cationic Lipids in Gene Transfer 5. Polymer-Based Gene Delivery Systems 6. Adenoviral Vectors for Gene Delivery 7. Gene Delivery Technology: Adeno-Associated Virus 8. Retrovectors Go Forward 9. Device-Mediated Gene Delivery: A Review 10. Nonviral Approaches for Cancer Gene Therapy 11. Replicating Adenoviral Vectors for Cancer Therapy 12. Cardiovascular Gene Therapy 13. Pulmonary Gene Therapy

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Polymer Therapeutics 1, 2
Polymers as Drugs, Conjugates and Gene Delivery Systems


Polymer Therapeutics I Polymers as Drugs, Conjugates and Gene Delivery Systems (Advances in Polymer Science, Vol. 192)
Publisher: Springer
ISBN: 3540292104 2006 Pages: 213 PDF 4.8 MB

Table of contents
1 Duncan, H. Ringsdorf, R. Satchi-Fainaro: Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities.-2 P.K. Dhal, S.R. Holmes-Farley, C.C. Huval, T.H. Jozefiak: Polymers as Drugs.-3 R.J. Amir, D. Shabat: Domino Dendrimers.-4 G. Pasut, F.M. Veronese: PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates.- E. Wagner, J. Kloeckner: Gene Delivery Using Polymer Therapeutics.-

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Polymer Therapeutics II

Polymers as Drugs, Conjugates and Gene Delivery Sytems (Advances in Polymer Science, Vol. 193)

Polymer Therapeutics II Polymers as Drugs, Conjugates and Gene Delivery Sytems (Advances in Polymer Science, Vol. 193)Publisher: Springer ISBN: 3540292111 2006 Pages: 200 PDF 3.9 MB

Table of contents1 R. Satchi-Fainaro, R. Duncan, C.M. Barnes: Polymer Therapeutics for Cancer: Current Status and Future Challenges.-2 N. Nishiyama, K. Kataoka: Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function.-3 H. Maeda, K. Greish, J. Fang: The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century.-4 J.S. Ellis, S. Allen, Y.T. A. Chim, C.J. Roberts, S.J.B. Tendler, M.C. Davies: Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy.-5 A.V. Kabanov, E.V. Batrakova, S. Sherman, V.Y. Alakhov: Polymer Genomics.-

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Local Drug Delivery for Coronary Artery Disease: Established and Emerging Applications
Edoardo Camenzind, Ivan De Scheerder "Local Drug Delivery for Coronary Artery Disease: Established and Emerging Applications"Inf HealthCare 2005-06-14 ISBN: 1841840459 608 pages PDF 9 MB

Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall. With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.

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Polymeric drugs & drug delivery systems
by Ottenbrite Polymeric
CRC Press ISBN: 1566769566 2001 Pages: 313 PDF 8.9 MB
The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future. - Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin
Product DescriptionPolymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensor sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume publishes consists of twenty-two recent research-based reports reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratoriesresearch organizations in the U.S.A., Europe, and Far EastAsia. These 22 chaptersThese 22 chapters report the latest information in the application of polymers to biological systems.

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Ophthalmic Drug Delivery Systems, Second Edition

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.

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Design of Controlled Release Drug Delivery Systems

The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

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Inhalation Delivery of Therapeutic Peptides and Proteins Inhalation Delivery of Therapeutic Peptides and Proteins (Lung Biology in Health and Disease)
by Akwete Adjei Informa HealthCare 952 pages 1997-07-08
ISBN: 0824797809 PDF 8.3mb

This exhaustive reference;the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems;offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs;especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses airway physiology and biomechanics the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace and much more!

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Enhancement in Drug Delivery Elka Touitou, Brian W. Barry, " Enhancement in Drug Delivery" CRC; 1 edition (November 27, 2006) ISBN:0849332036 656 pages PDF 6,1 Mb
Enhancement in Drug Delivery offers an accessible compendium covering a wide spectrum of methods to enhance drug delivery and absorption by various routes of administration. Drawing from a number of disciplines, it gives students and practitioners in pharmaceutics, medicine, and health-related disciplines a much-needed guide to current practices. It also provides a starting place for those working on delivery systems for new drugs or seeking to improve current systems by drawing on means applied in other routes. Organized by routes of delivery, the book covers oral, rectal, buccal and sublingual, dermal and transdermal, ocular, vaginal and uterine, nasal and brain administrations.

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Transdermal Drug Delivery, Second EditionTransdermal Drug Delivery,
Second Edition
Publisher:Informa Healthcare 2002-10-29
ISBN:082470861X Pages: 328 PDF 5.4 MB

Book Description:
Completely revised, the Second Edition of Transdermal Drug Delivery presents discussions of the key issues pertinent to transdermal drug delivery. Covering the depth and breadth of the field, from physical chemistry and assessment of drug permeability to available enhancement technologies, to regulatory approval, the book examines topics necessary to the critical evaluation of a drug candidate's potential for delivery across the skin. It describes how to determine the transdermal permeability of drugs, how rationally to select candidates for transdermal delivery, how to choose chemical and/or physical methods to enhance skin transport, and how to solve regulatory issues.

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Xiaoling Li, " Design of Controlled Release Drug Delivery Systems"
McGraw-Hill Professional; 1 edition (November 3, 2005)
ISBN: 0071417591 435 pages PDF 3,3 Mb


Written by an International team of experts, this comprehensive text offers pharmaceutical scientists and engineers working in the field, state-of-the-art design principles for the development and bioengineering of drug delivery systems/technology. Readers will find drug delivery systems presented with a particular emphasis on the design principles and their physiological/pathological basis. For each specific design principle, the contributors briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome.
This in-depth text features detailed coverage of:Physiological and biochemical barriers to drug deliveryPharmacokinetics and pharmacodynamics of drug deliveryDiffusion and dissolution strategiesProdrugsBioadhesive and gastric retentive systemsPhysiological and biochemical barriers to drug deliveryTargeted drug deliveryDevice controlled and programmable drug deliveryAnd more

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Enhancement in Drug DeliveryElka Touitou, Brian W. Barry, " Enhancement in Drug Delivery" CRC; 1 edition (November 27, 2006)
ISBN:0849332036 656 pages PDF 6,1 Mb

Enhancement in Drug Delivery offers an accessible compendium covering a wide spectrum of methods to enhance drug delivery and absorption by various routes of administration. Drawing from a number of disciplines, it gives students and practitioners in pharmaceutics, medicine, and health-related disciplines a much-needed guide to current practices. It also provides a starting place for those working on delivery systems for new drugs or seeking to improve current systems by drawing on means applied in other routes. Organized by routes of delivery, the book covers oral, rectal, buccal and sublingual, dermal and transdermal, ocular, vaginal and uterine, nasal and brain administrations.

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Cellular Drug Delivery: Principles and Practice
D. Robert Lu, Svein ?ie
“Cellular Drug Delivery: Principles and Practice" Humana Press 2004-02-25
ISBN: 1588292541 392 pages PDF 9,7 MB

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

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Modified-Release Drug Delivery Technology

ISBN: 0824708695
Title: Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs), 2002-11
Author: Michael J. Rathbone (Editor), Jonathan Hadgraft (Editor), Michael S. Roberts (Editor)Publisher: Informa HealthcarePublication
Date: 2002-11-07
Number Of Pages: 1032:

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

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Biochemistry

The trusted, best-selling text for organic chemistry just got better! Updated with the latest developments, expanded with more illustrations and "Visualizing Chemistry" problems, and enhanced with new media-based "Organic Knowledge Tools," John McMurry's ORGANIC CHEMISTRY continues to set the standard for the course. The Seventh Edition also retains McMurry's hallmark qualities: comprehensive, authoritative, and clear. McMurry has developed a reputation for crafting precise and accessible texts that speak to the needs of instructors and students. More than a million students worldwide from a full range of universities have explored organic chemistry through his trademark style, while instructors have praised his approach time and time again.

Table of Contents:
1. Structure and Bonding.
2. Polar Covalent Bonds; Acids and Bases.
3. Organic Compounds: Alkanes and Their Stereochemistry.
4. Organic Compounds: Cycloalkanes and Their Stereochemistry.
5. An Overview of Organic Reactions.
6. Alkenes: Structure and Reactivity.
7. Alkenes: Reactions and Synthesis.
8. Alkynes: An Introduction to Organic Synthesis.
9. Stereochemistry.
10. Organohalides.
11. Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations.
12. Structure Determination: Mass Spectrometry and Infrared Spectroscopy.
13. Structure Determination: Nuclear Magnetic Resonance Spectroscopy.
14. Conjugated Compounds and Ultraviolet Spectroscopy.
15. Benzene and Aromaticity.
16. Chemistry of Benzene: Electrophilic Aromatic Substitution.
17. Alcohols and Phenols.
18. Ethers and Epoxides; Thiols and Sulfides. A Preview of Carbonyl Compounds.
19. Aldehydes and Ketones: Nucleophilic Addition Reactions.
20. Carboxylic Acids and Nitriles.
21. Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions.
22. Carbonyl Alpha-Substitution Reactions.
23. Carbonyl Condensation Reactions.
24. Amines and Heterocycles.
25. Biomolecules: Carbohydrates.
26. Biomolecules: Amino Acids, Peptides, and Proteins.
27. Biomolecules: Lipids.
28. Biomolecules: Nucleic Acids.
29. The Organic Chemistry of Metabolic Pathways.
30. Orbitals and Organic Chemistry: Pericyclic Reactions.
31. Synthetic Polymers.

John E. McMurry - Cornell University
ISBN-10: 0495112585
ISBN-13: 9780495112587
1344 Pages Casebound
Category: Books Size: 79.87 MB

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Lehninger Principles of Biochemistry, Fourth Edition

This is a medium-sized heavyweight classic, updated, honest and useful for physicians. The authors do not make a fuss about the wealth of data available in biochemistry, keep a cool attitude overall and somehow manage to inspire lay readers. Physicians benefit from it a lot, since the dreaded detail of molecular pathology is described at an amazing level of medical awareness and even clinical relevance. Molecular models are clear enough for the busy practitioner who has little if any real interest in the arcane wireframes of those nevertheless current substances involved in prescriptions. The print is fine, and readable, the pagesetting is minimalist but useful, and the index is workable. As for the biochemical material, in the original text of Lehninger, everything has been carefully updated, in order not to spoil the reader with the usual Big Pharma nonsense. Incredible as it may sound this is an independent book even in the Age of Virtual News. Highly Reccommended. In conclusion, here we have a book we will not buy for the beauty of our reference desk, even in the age of the instant reference

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Wednesday, July 1, 2009

Biochemistry

Biochemistry E-Books Collection :

♥ "Boyer-Modern Experimental Biochemistry 3e","","","","E-Book"
♥ "Garrett and Grisham-Biochemistry 2ed","","","","E-Book"
♥ "Hiram F. Gilbert-Basic Concepts in Biochemistry A Student's Survival Guide 2d ed","","","","E-Book"
♥ "Jeremy M. Berg, John L. Tymoczko, Lubert Stryer-Biochemistry 5th ed.","","","","E-Book"
♥ "Kaplan Biochemistry (2006-2007)","","","","E-Book"
♥ "Koolman, Roehm-Color Atlas of Biochemistry, 2nd Ed","","","","E-Book"
♥ "Lehninger-Biochemistry 4ed 2004","","","","E-Book"
♥ "Lubert Stryer - Biochemistry-5th edition","Jeremy M. Berg, John L. Tymoczko, Lubert Stryer.","","W.H.Freeman ","E-Book"
♥ "Metzler-Biochemistry The Chemical Reactions of Living Cells 2e Vols 1-2","","","","E-Book"
♥ "Murray-Harper's Illustrated Biochemistry 26th Ed","","","","E-Book"
♥ "USMLE Road Map Biochemistry","","","","E-Book"

Basic concepts in biochemistry 2ed - Gilbert,"E-Book"
Biochemistry 2ed - Garrett & Grisham ,"E-Book"
Biochemistry 3ed - Lippincott,"E-Book"
Biochemistry 3ed - Mathews,"E-Book"
Dictionary of biochemistry and molecular biology 2ed - Stenesh,"E-Book"
Encyclopedia of Biological Chemistry - Vol_1,"E-Book"
Encyclopedia of Biological Chemistry - Vol_2,"E-Book"
Encyclopedia of Biological Chemistry - Vol_3,"E-Book"
Encyclopedia of Biological Chemistry - Vol_4,"E-Book"

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Biochemistry
W. H. Freeman ISBN:0716746824 Fifth Edition - 2002 PDF 1514 pages 25.6 MB

Biochemistry

For more than 25 years, and through four editions, Stryer's Biochemistry has laid out this beautiful subject in an exceptionally appealing and lucid manner. The engaging writing style and attractive design have made the text a pleasure for our students to read and study throughout our years of teaching. Thus, we were delighted to be given the opportunity to participate in the revision of this book. The task has been exciting and somewhat daunting, doubly so because of the dramatic changes that are transforming the field of biochemistry as we move into the twenty-first century. Biochemistry is rapidly progressing from a science performed almost entirely at the laboratory bench to one that may be explored through computers. The recently developed ability to determine entire genomic sequences has provided the data needed to accomplish massive comparisons of derived protein sequences, the results of which may be used to formulate and test hypotheses about biochemical function. The power of these new methods is explained by the impact of evolution: many molecules and biochemical pathways have been generated by duplicating and modifying existing ones. Our challenge in writing the fifth edition of Biochemistry has been to introduce this philosophical shift in biochemistry while maintaining the clear and inviting style that has distinguished the preceding four editions.

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Principles of Biochemical Toxicology, Fourth Edition

John A. Timbrell, "Principles of Biochemical Toxicology, Fourth Edition"
Informa HealthCare 2008-11-18 ISBN: 0849373026 520 p PDF 8 Mb
This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching. New to the Fourth Edition:
reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more questions with answers for each chapter for review and self-checking expanded and updated chapter bibliographiesd

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Biochemistry, 5th Edition, 2002-02

Biochemistry, 5th Edition, 2002-02

ISBN: 0716746840 Title: Biochemistry, 5th Edition, 2002-02

Author: Jeremy M. Berg, John L. Tymoczko, Lubert Stryer

Publisher: W. H. Freeman pages: 1100 PDF 26.18 MB

Reviewer:
This is a superb book to understand the excitement in biochemistry and to understand its relevance to human health. Stryer's book presents biochemistry in a completely different manner. Instead of traditionally presenting one topic after the other, it presents each chapter giving a representative molecule or system for explanation and characterization of the material in that chapter . For example, heamoglobin and myoglobin for explaining the three dimensional structure of proteins, lysozyme and chymotrypsin for explaining enzyme action, and a host of others. Each example is critically chosen, considering its role and function in life and metabolism. This makes the matter very interesting and practical. Paralleling this are given descriptions of diseases and biochemical disorders as well as historical perspectives. The last part, molecular physiology, gives a lucid exposition of the fundamental biochemical processes in living organisms. In fact, the whole point of view in the book is a physiological one. The book is unlike Lehninger, which is essentially a traditional textbook. Even though Lehninger is great as an introductory book, Stryer is, in my opinion, the book to read if you want to learn biochemistry as a discipline which should be viewed as an exciting excursion into human metabolism and life.

Review of new edition (Berg, Tymockzo):
I had written a favourable review earlier for a previous edition of Stryer. I rest my case for the latest edition too. Jeremy Berg and John Tymoczko, both accomplished authors, join Lubert Stryer in producing this time tested and comprehensive book. If you are someone like me, who believes that enzymes and proteins are the key to understanding the mysteries of life, then this book is for you. While it may not have as much coverage of nucleic acid chemistry biochemistry as some of the other books, I believe that the next revolution in biology is going to hinge upon our understanding of SYSTEMS. And while an understanding of genes is crucial as enabling knowledge, if you really consider all the actual action that happens in biochemical systems, almost all of it is mediated by enzymes and receptors. Stryer's new edition has literally hundreds of pictures and discussions of proteins and enzymes which explain the structure and function of these magnificent biological agents. The book has still retained the concise and yet comprehensive style which made its previous edition so good. Again, the book strikes a good balance between textbook and medical biochemistry, which is its great strength. Small boxes and side discussions throw light on the most interesting events connected with drug metabolism and disease. As a side point, the discussions about nucleic acid biology which the authors HAVE included are pretty good in themselves. Biochemistry is one of the most exciting branches of scientific research. This is because first of all it is highly interdisciplinary, enjoying a wonderful synergy with organic and inorganic chemistry, physical chemistry and physics, and of course, biology. Secondly, Biochemistry is an extraordinarily dynamic subject and biochemical knowledge doubles every five years. Discoveries in biochemistry directly affect medical science. In the 21st century, it continues to promise us radical understanding into the working of life, and any good biochemistry book should ideally convey this excitement to the reader. This one does. The bottom line is, if you want to get excited about the miracle that is called life, and want to do it in a rational way, Stryer is still one of the very best. I hope it continues to be so.

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Basic Concepts in Biochemistry: A Student's Survival Guide
Basic Concepts in Biochemistry_A Student's Survival Guide

Paperback: 331 pages
Data: November 16, 1999
Format: PDF
Description: This second edition continues to innovatively review the toughest concepts in biochemistry for maximum comprehension in a short period of time. Unlike conventional texts or review books that stress memorizing facts, BASIC CONCEPTS stresses the mastering of fundamental concepts, so that the reader truly comprehends the material and feels comfortable applying it. Dr. Gilbert uses simple, jargon-free language and award-winning teaching techniques including algorithms, mnemonics and clinical examples.

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Color Atlas Of Biochemistry



Color Atlas Of Biochemistry

Paperback: 467 pages
Data: December 2004
Format: PDF
Description: Basic biochemistry in color pictures! This book focuses on particular and fundamental aspects of human and mammalian biochemistry. Besides coverage of structure and composition of biologically relevant molecules and their metabolism, it also includes interlinking of chemical structures with biological functions, how molecules are arranged in cellular space and in the organism, and the evolution of biochemical processes.

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Marks' Basic Medical Biochemistry: A Clinical Approach, 2nd edition



Marks' Basic Medical Biochemistry_A Clinical Approach, 2nd edition

Colleen Smith, Allan Marks, Michael A Lieberman, "Marks' Basic Medical Biochemistry: A Clinical Approach"ISBN: 0781721458 Publisher: Lippincott Williams & Wilkins August 1, 2004 2nd Edition 900 pages PDF English 46.5 mb
An excellent clinically based medical biochemistry book. Good examples of realistic cases.This best-selling resource utilizes a comprehensive yet practical approach that students understand. The authors present facts and pathways to emphasize how the underlying biochemistry is related to the body's overall physiological functions. Detailed case studies show students the relationship between biochemistry and clinical problems.
The Second Edition has been heavily revised with completely updated illustrations while maintaining the unique, patient-oriented approach that made the original so popular. A new CD-ROM in the back of the book features chapter-by-chapter test questions, detailed 3-D representations of enzyme structure, PowerPoint slides, and real patient stories.
Table of Contents
1 Metabolic fuels and dietary components
32 The fed or absorptive state
223 Fasting
304 Water, acids, bases, and buffers
415 Structures of the major compounds of the body
546 Amino acids in proteins
727 Structure-function relationships in proteins
928 Enzymes as catalysts
1159 Regulation of enzymes
13810 Relationship between cell biology and biochemistry
15711 Cell signaling by chemical messengers
18412 Structure of the nucleic acids
20713 Synthesis of DNA
22214 Transcription : synthesis of RNA
23715 Translation : synthesis of proteins
25816 Regulation of gene expression
27417 Use of recombinant DNA techniques in medicine
29718 The molecular biology of cancer
31719 Cellular bioenergetics : ATP and O[subscript 2]
34120 Tricarboxylic acid cycle
36021 Oxidative phosphorylation and mitochondrial function
38022 Generation of ATP from glucose : glycolysis
39923 Oxidation of fatty acids and ketone bodies
41824 Oxygen toxicity and free radical injury
43925 Metabolism of ethanol
45826 Basic concepts in the regulation of fuel metabolism by insulin, glucagon, and other hormones
47727 Digestion, absorption, and transport of carbohydrates
49328 Formation and degradation of glycogen
51129 Pathways of sugar metabolism : pentose phosphate pathway, fructose, and galactose metabolism
52730 Synthesis of glycosides, lactose, glycoproteins, and glycolipids
54231 Gluconeogenesis and maintenance of blood glucose levels
55632 Digestion and transport of dietary lipids
58333 Synthesis of fatty acids, triacylglycerols, and the major membrane lipids
59434 Cholesterol absorption, synthesis, metabolism, and fate
61935 Metabolism of the eicosanoids
65436 Integration of carbohydrate and lipid metabolism
66837 Protein digestion and amino acid absorption
68738 Fate of amino acid nitrogen : urea cycle
69739 Synthesis and degradation of amino acids
71240 Tetrahydrofolate, vitamin B12, and S-adenosylmethionine
73241 Purine and pyrimidine metabolism
74742 Intertissue relationships in the metabolism of amino acids
76243 Actions of hormones that regulate fuel metabolism
78344 The biochemistry of the erythrocyte and other blood cells
80545 Blood plasma proteins, coagulation, and fibrinolysis
82746 Liver metabolism
84247 Metabolism of muscle at rest and during exercise 86248 Metabolism of the nervous system
88149 The extracelluar matrix and connective tissue 905

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General, Organic and Biochemistry (2003)

General, Organic and Biochemistry (2003)

General, Organic and BiochemistryPublisher:McGraw Hill Language: English ISBN:0071214518 896 pages Data: 2003 PDF 7 MbDescription: The fourth edition of General, Organic, and Biochemistry is designed to help undergraduate health-related majors and students of all other majors understand key concepts and appreciate the significant connections between chemistry, health, disease, and the treatment of disease. This text strikes a balance between theoretical and practical chemistry, while emphasizing material that is unique to health-related studies.General Chemistry 1 Chemistry: Methods and Measurement 2 The Composition and Structure of the Atom 3 Elements, Atoms, Ions, and the Periodic Table 4 Structure and Properties of Ionic and Covalent Compounds 5 Calculations and the Chemical Equation 6 States of Matter: Gases, Liquids, and Solids 7 Reactions and Solutions 8 Chemical and Physical Change: Energy, Rate, and Equilibrium 9 Charge-Transfer Reactions: Acids and Bases and Oxidation-Reduction 10 The Nucleus, Radioactivity, and Nuclear Medicine Organic Chemistry 11 An Introduction to Organic Chemistry: The Saturated Hydrocarbons 12 The Unsaturated Hydrocarbons: Alkenes, Alkynes, and Aromatics 13 Alcohols, Phenols, Thiols, and Ethers 14 Aldehydes and Ketones 15 Carboxylic Acids and Carboxylic Acid Derivatives 16 Amines and Amides Biochemistry 17 Carbohydrates 18 Lipids and Their Functions in Biochemical Systems 19 Protein Structure and Function 20 Enzymes 21 Carbohydrate Metabolism 22 Aerobic Respiration and Energy Production 23 Fatty Acid Metabolism 24 Introduction to Molecular Genetics Appendixes

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Clinical Biochemistry Made Ridiculously Simple

Clinical Biochemistry Made Ridiculously Simple

Stephen Goldberg, ?Clinical Biochemistry Made Ridiculously Simple? MedMaster ISBN: 0940780305 2001 edition (2004) PDF 93 pages 29 Mb
Focuses on the basic conceptual background of clinically relevant biochemistry for medical students and other health professionals.
Graduate students and medical students have different needs in their learning of biochemistry. Medical students often complain that their biochemistry courses do not focus on clinical relevance. This book, while not a reference book or a dissertation on all aspects of biochemistry, selects the most clinically relevant material that every clinician should know, and presents it in a way that enables the student to quickly see and understand clinical biochemistry as a conceptual whole.
Links:
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Instant Notes in Biochemistry (Instant Notes)

Instant Notes in Biochemistry (Instant Notes)
Instant Notes in Biochemistry (Instant Notes)

Publisher:Taylor & Francis Pages:438 2005-11-10

ISBN:0415367786 PDF 3.4 MB

Instant Notes titles focus on core information and are designed to help undergraduate students come to grips with a subject quickly and easily.A major update of the highly popular second edition, with changes in the content and organization that reflect advances in the subject. New and expanded topics include cytoskeleton, molecular motors, bioimaging, biomembranes, cell signaling, protein structure, and enzyme regulation. As with the first two editions, the third edition of Instant Notes in Biochemistry provides the essential facts of biochemistry with detailed explanations and clear illustrations.

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Lehninger, Principle of Biochemistry, 3rd/4th Ed.
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Stryer, Biochemistry, 4th/5th Ed.
4 Ed
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Friday, June 19, 2009

Mobile Telemedicine





Mobile Telemedicine:


A Computing and Networking Perspective (Hardcover)


Editorial Reviews


Product DescriptionAdvances in the area of wireless and mobile telemedicine to diagnose and treat patients have drawn growing attention from healthcare providers and recipients, industry, researchers, and governments.This volumeexamines computing and network dilemmas which arise from wireless and mobile telemedicine. Comprised of the contributions of many prominent international researchers, the book gives an overview of patient care and monitoring, discusses the use of telemedicine in cardiology and diabetes, analyzes security and privacy considerations, examines issues relating to networking support, and concludes with a section on the opportunities and challenges that are faced by those involved in this exciting technology.


Product Details


Hardcover: 440 pages


Publisher: Auerbach


Publications; 1 edition (June 3, 2008)


Language: English


ISBN-10: 1420060465


ISBN-13: 978-1420060461


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Telemedicine in the 21st Century (Hardcover)


by Lucia Martinez (Editor), Carla Gomez (Editor)


Editorial ReviewsProduct DescriptionTelemedicine is a rapidly developing application of clinical medicine where medical information is transferred via telephone, the Internet or other networks for the purpose of consulting, and sometimes remote medical procedures or examinations. Telemedicine may be as simple as two health professionals discussing a case over the telephone, or as complex as using satellite technology and video-conferencing equipment to conduct a real-time consultation between medical specialists in two different countries. Telemedicine generally refers to the use of communications and information technologies for the delivery of clinical care. This book presents the latest research in this field from around the globe.


Product Details


Hardcover: 279 pages


Publisher: Nova Science


Publishers; 1 edition (August 2008)


Language: English


ISBN-10: 1604566450


ISBN-13: 978-1604566451

History of Telemedicine



History of Telemedicine: Evolution, Context, and Transformation
Editorial ReviewsReviewAs someone who thought he knew most of what had gone before, and how the field had matured, I found very early into this scholarly, incredibly well researched, and comprehensive manuscript how much more I needed to learn. This will now become my reference source and there is little doubt that it will be the Encyclopedia of Telemedicine. The authors create the feeling in the reader that telemedicine is not simply an enabling technology, but more of an umbilical cord of health information exchange. --Jay Sanders, MD, Global Telemedicine Group
As someone who thought he knew most of what had gone before, and how the field had matured, I found very early into this scholarly, incredibly well researched, and comprehensive manuscript how much more I needed to learn. This will now become my reference source and there is little doubt that it will be the Encyclopedia of Telemedicine. The authors create the feeling in the reader that telemedicine is not simply an enabling technology, but more of an umbilical cord of health information exchange. --Jay Sanders, MD, Global Telemedicine Group

Few researchers have been as involved in the modern era of telemedicine as Bashshur and Shannon. They have produced a work that is comprehensive, carefully researched, intellectually rigorous, and very well written. The authors have managed to bring this history to life, weaving anecdotes and personal accounts of telemedicine s development and evolution into the research literature. For the reader who wishes to understand how telemedicine got to where it is today, this book is essential. --Jim Grigsby, PhD, University of Colorado Denver

Telemedicine has finally received the interesting and balanced historical recognition it deserves. Drs. Bashshur and Shannon have produced an excellent, exhaustive history of this method of delivering health care, from smoke signals in ancient Greece to today's instant computer communications, including stereo vision and haptics. The current state of the art of telemedicine is filled with impersonal high-tech devices and methods, but the authors never lose sight of the field's primary goal: to improve patient care and benefit the public health. --Donald A.B. Lindberg, MD, Director, National Library of Medicine
Few researchers have been as involved in the modern era of telemedicine as Bashshur and Shannon. They have produced a work that is comprehensive, carefully researched, intellectually rigorous, and very well written. The authors have managed to bring this history to life, weaving anecdotes and personal accounts of telemedicine s development and evolution into the research literature. For the reader who wishes to understand how telemedicine got to where it is today, this book is essential. --Jim Grigsby, PhD, University of Colorado Denver
Product DescriptionThe History of Telemedicine provides a comprehensive and in-depth analysis of the evolution of telemedicine from ancient Greece to the present time. It places the development of this field in the context of the never ending quest for providing equitable access to health care and re-casting the medical care landscape, while trying to assure quality and contain cost. The book describes the origin of modern telemedicine in experiments such as those by Willem Einthoven s 1905 long distance transfer of electrocardiograms through the pioneering era of teleradiology and telepsychiatry of the 1950s, its coming of age in the 1970s, its maturation in the 1990s, and finally the recent transformation and adoption by the mainstream. The authors delve into the rich history of telemedicine and tell the story from its genesis to the present time, reporting its continuity and evolution, its various adaptations, and the context that sustained interest and development in this modality of care and continues to guide its transformation into the future. The authors central theme throughout the book is telemedicine s potential role in improving human health.

Product Details
Hardcover: 415 pages
Publisher: Mary Ann Liebert (April 15, 2009)
Language: English
ISBN-10: 1934854115
ISBN-13: 978-193485411