Wednesday, July 8, 2009

Drug Delivery System

Pharmaceutical gene drug delivery systems


This reference discusses advances in the design, optimization, and adaption of gene delivery systems for treatment of cancerous, cardiovascular, pulmonary, genetic, and infectious diseases. Pharmaceutical Gene Delivery Systems also contains assessment and reviews on procedures involved in the development of gene-based pharmaceuticals. It examines the advantages and limitations of the major gene delivery systems, as well as offers guidelines to select the most appropriate viral or synthetic delivery system for specific theraputic applications. Pharmaceutical Gene Delivery: • examines recent breakthroughs in gene therapy • details new technologies such as artificial chromosome delivery • covers the preclinical data required for investigational new drug applicationfiling • exemplifies several therapeutic applications of gene therapy products Contents 1. Introduction to Gene Therapy and Guidelines to Pharmaceutical Development 2. Sustaining Transgene _Expression in Vivo 3. _Expression Systems: Regulated Gene _Expression 4. Mechanisms for Cationic Lipids in Gene Transfer 5. Polymer-Based Gene Delivery Systems 6. Adenoviral Vectors for Gene Delivery 7. Gene Delivery Technology: Adeno-Associated Virus 8. Retrovectors Go Forward 9. Device-Mediated Gene Delivery: A Review 10. Nonviral Approaches for Cancer Gene Therapy 11. Replicating Adenoviral Vectors for Cancer Therapy 12. Cardiovascular Gene Therapy 13. Pulmonary Gene Therapy

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Polymer Therapeutics 1, 2
Polymers as Drugs, Conjugates and Gene Delivery Systems


Polymer Therapeutics I Polymers as Drugs, Conjugates and Gene Delivery Systems (Advances in Polymer Science, Vol. 192)
Publisher: Springer
ISBN: 3540292104 2006 Pages: 213 PDF 4.8 MB

Table of contents
1 Duncan, H. Ringsdorf, R. Satchi-Fainaro: Polymer Therapeutics: Polymers as Drugs, Drug and Protein Conjugates and Gene Delivery Systems: Past, Present and Future Opportunities.-2 P.K. Dhal, S.R. Holmes-Farley, C.C. Huval, T.H. Jozefiak: Polymers as Drugs.-3 R.J. Amir, D. Shabat: Domino Dendrimers.-4 G. Pasut, F.M. Veronese: PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates.- E. Wagner, J. Kloeckner: Gene Delivery Using Polymer Therapeutics.-

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Polymer Therapeutics II

Polymers as Drugs, Conjugates and Gene Delivery Sytems (Advances in Polymer Science, Vol. 193)

Polymer Therapeutics II Polymers as Drugs, Conjugates and Gene Delivery Sytems (Advances in Polymer Science, Vol. 193)Publisher: Springer ISBN: 3540292111 2006 Pages: 200 PDF 3.9 MB

Table of contents1 R. Satchi-Fainaro, R. Duncan, C.M. Barnes: Polymer Therapeutics for Cancer: Current Status and Future Challenges.-2 N. Nishiyama, K. Kataoka: Nanostructured Devices Based on Block Copolymer Assemblies for Drug Delivery: Designing Structures for Enhanced Drug Function.-3 H. Maeda, K. Greish, J. Fang: The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century.-4 J.S. Ellis, S. Allen, Y.T. A. Chim, C.J. Roberts, S.J.B. Tendler, M.C. Davies: Molecular-Scale Studies on Biopolymers Using Atomic Force Microscopy.-5 A.V. Kabanov, E.V. Batrakova, S. Sherman, V.Y. Alakhov: Polymer Genomics.-

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Local Drug Delivery for Coronary Artery Disease: Established and Emerging Applications
Edoardo Camenzind, Ivan De Scheerder "Local Drug Delivery for Coronary Artery Disease: Established and Emerging Applications"Inf HealthCare 2005-06-14 ISBN: 1841840459 608 pages PDF 9 MB

Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall. With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.

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Polymeric drugs & drug delivery systems
by Ottenbrite Polymeric
CRC Press ISBN: 1566769566 2001 Pages: 313 PDF 8.9 MB
The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are all extremely creative and interesting. This reviewer would recommend this book as it presents a broad selection of some very interesting directions that polymer drug delivery will be taking in the near future. - Lisa Brannon-Peppas, PhD, The Department of Biomedical Engineering, The University of Texas at Austin
Product DescriptionPolymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensor sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume publishes consists of twenty-two recent research-based reports reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratoriesresearch organizations in the U.S.A., Europe, and Far EastAsia. These 22 chaptersThese 22 chapters report the latest information in the application of polymers to biological systems.

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Ophthalmic Drug Delivery Systems, Second Edition

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs.

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Design of Controlled Release Drug Delivery Systems

The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

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Inhalation Delivery of Therapeutic Peptides and Proteins Inhalation Delivery of Therapeutic Peptides and Proteins (Lung Biology in Health and Disease)
by Akwete Adjei Informa HealthCare 952 pages 1997-07-08
ISBN: 0824797809 PDF 8.3mb

This exhaustive reference;the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems;offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs;especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses airway physiology and biomechanics the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace and much more!

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Enhancement in Drug Delivery Elka Touitou, Brian W. Barry, " Enhancement in Drug Delivery" CRC; 1 edition (November 27, 2006) ISBN:0849332036 656 pages PDF 6,1 Mb
Enhancement in Drug Delivery offers an accessible compendium covering a wide spectrum of methods to enhance drug delivery and absorption by various routes of administration. Drawing from a number of disciplines, it gives students and practitioners in pharmaceutics, medicine, and health-related disciplines a much-needed guide to current practices. It also provides a starting place for those working on delivery systems for new drugs or seeking to improve current systems by drawing on means applied in other routes. Organized by routes of delivery, the book covers oral, rectal, buccal and sublingual, dermal and transdermal, ocular, vaginal and uterine, nasal and brain administrations.

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Transdermal Drug Delivery, Second EditionTransdermal Drug Delivery,
Second Edition
Publisher:Informa Healthcare 2002-10-29
ISBN:082470861X Pages: 328 PDF 5.4 MB

Book Description:
Completely revised, the Second Edition of Transdermal Drug Delivery presents discussions of the key issues pertinent to transdermal drug delivery. Covering the depth and breadth of the field, from physical chemistry and assessment of drug permeability to available enhancement technologies, to regulatory approval, the book examines topics necessary to the critical evaluation of a drug candidate's potential for delivery across the skin. It describes how to determine the transdermal permeability of drugs, how rationally to select candidates for transdermal delivery, how to choose chemical and/or physical methods to enhance skin transport, and how to solve regulatory issues.

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Xiaoling Li, " Design of Controlled Release Drug Delivery Systems"
McGraw-Hill Professional; 1 edition (November 3, 2005)
ISBN: 0071417591 435 pages PDF 3,3 Mb


Written by an International team of experts, this comprehensive text offers pharmaceutical scientists and engineers working in the field, state-of-the-art design principles for the development and bioengineering of drug delivery systems/technology. Readers will find drug delivery systems presented with a particular emphasis on the design principles and their physiological/pathological basis. For each specific design principle, the contributors briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome.
This in-depth text features detailed coverage of:Physiological and biochemical barriers to drug deliveryPharmacokinetics and pharmacodynamics of drug deliveryDiffusion and dissolution strategiesProdrugsBioadhesive and gastric retentive systemsPhysiological and biochemical barriers to drug deliveryTargeted drug deliveryDevice controlled and programmable drug deliveryAnd more

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Enhancement in Drug DeliveryElka Touitou, Brian W. Barry, " Enhancement in Drug Delivery" CRC; 1 edition (November 27, 2006)
ISBN:0849332036 656 pages PDF 6,1 Mb

Enhancement in Drug Delivery offers an accessible compendium covering a wide spectrum of methods to enhance drug delivery and absorption by various routes of administration. Drawing from a number of disciplines, it gives students and practitioners in pharmaceutics, medicine, and health-related disciplines a much-needed guide to current practices. It also provides a starting place for those working on delivery systems for new drugs or seeking to improve current systems by drawing on means applied in other routes. Organized by routes of delivery, the book covers oral, rectal, buccal and sublingual, dermal and transdermal, ocular, vaginal and uterine, nasal and brain administrations.

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Cellular Drug Delivery: Principles and Practice
D. Robert Lu, Svein ?ie
“Cellular Drug Delivery: Principles and Practice" Humana Press 2004-02-25
ISBN: 1588292541 392 pages PDF 9,7 MB

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

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Modified-Release Drug Delivery Technology

ISBN: 0824708695
Title: Modified-Release Drug Delivery Technology (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs), 2002-11
Author: Michael J. Rathbone (Editor), Jonathan Hadgraft (Editor), Michael S. Roberts (Editor)Publisher: Informa HealthcarePublication
Date: 2002-11-07
Number Of Pages: 1032:

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

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